|Search for predicted fly microRNA targets||[Go to TargetScanHuman]|
|[Go to TargetScanMouse]|
|[Go to TargetScanWorm]|
|[Go to TargetScanFish]|
*conserved = conserved at least among most Drosophilids in the Melanogaster group
TargetScan predicts biological targets of microRNAs by searching for the presence of conservedand sites that match the of each microRNA (Lewis et al., 2005). As an option, predictions with only poorly conserved sites are also provided. In flies, predictions are ranked based on the predicted efficacy of targeting as calculated using cumulative weighted of the sites (Agarwal et al., 2018). As an option, predictions are also ranked by their probability of conserved targeting (PCT, Friedman et al., 2009, Agarwal et al., 2018). TargetScanFly considers matches to fly 3' UTRs and their orthologs, as defined by UCSC whole-genome alignments. Conserved targeting has also been detected within fly open reading frames (ORFs), and predictions for sites in fly ORFs are provided at TargetScanFly ORFs.
This search page of TargetScanFly Release 7.2 retrieves predicted regulatory targets of fly microRNAs. Many targets are the same as those presented in previous versions of the TargetScan site (Releases 4.0 - 4.1, 6.0 - 6.2) (Ruby et al., 2007; Jan et al., 2011). Compared to previous releases, Release 7 uses an improved method to predict targeting efficacy (the context model, Agarwal et al., 2018), uses 3' UTR profiles that indicate the fraction of mRNA containing each site (Nam et al., 2014), and uses updated miRNA families.
An introduction to microRNAs (iBioseminar)
Frequently Asked Questions (FAQs)
More information about TargetScanFly Release 7.2
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