The context++ score (CS) for a specific site is the sum of the contribution of 14 features (Agarwal et al., 2015):
- site type
- supplementary pairing
- local AU
- minimum distance
- sRNA1A*
- sRNA1C*
- sRNA1G*
- sRNA8A*
- sRNA8C*
- sRNA8G*
- site8A*
- site8C*
- site8G*
- 3' UTR length*
- SA*
- ORF length*
- ORF 8mer count*
- 3' UTR offset 6mer count*
- TA (target site abundance)
- SPS (seed-pairing stability)
- PCT (probability of conserved targeting)*
*new for TargetScanHuman 7 and TargetScanMouse 7